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BCAAs metabolism is altered in various tumors such as PDAC, NSCLC, BRCA, GBM, etc

Mutations in these regions can disturb GTP binding and lead to decreased sensitivity of GDH to allosteric regulation by GTP, resulting in weakened inhibitory effect and enhanced GDH activity [12]

Curcumin, a natural NF-B inhibitor, has been studied in the context of neurodegenerative and metabolic diseases, but its therapeutic value remains inconsistent owing to its poor bioavailability and rapid metabolism

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Scientists once thought that plants didnt make B12 nor need it for their growth and development